CORDIS Project
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This project investigates somatic mutations in the arterial wall to understand their role in age-related cardiovascular disease. By creating a detailed atlas of these mutations at single-cell resolution, the research aims to link genetic changes to the progression of cardiovascular conditions.
Already in 1973, Benditt and Benditt found that the atherosclerotic plaque was clonal and proposed that it was a neoplasm of vascular smooth muscle cells (VSMC).
Recent technical advances have made it possible to analyze somatic mutations in human tissues and show that somatic cells accumulate thousands of mutations during development and aging.
While most of the mutations are harmless, some either contribute to disease and aging or are directly disease-causative, as in the formation of tumors i…
KAROLINSKA INSTITUTET
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