CORDIS Project
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This project investigates the activity of transposable elements, specifically LINEs, in somatic cells during early embryogenesis using an in vivo mouse model. The aim is to understand how these elements contribute to genomic plasticity and gene regulation across different germ layers.
The human genome is largely composed of non-coding DNA, only 3-5% codes for exons.
The majority of the non-coding DNA is however fundamental for the correct functioning and regulation of the genome.
Transposable elements (TEs) like LINEs generated up to 50% of the human genome during evolution.
They can mobilize, causing mutations but also conferring genomic plasticity.
The generation of new insertions in the germ line led to the concept of TEs as ‘selfish’ DNA.
However, inconsistent with their…
FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD M.P.
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