CORDIS Project
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This project aims to develop advanced solid-state nuclear magnetic resonance methods for studying protein dynamics at high frequencies. It focuses on optimizing techniques to analyze small protein samples, enhancing sensitivity and accuracy in structural biology research.
This proposal concerns the development of new solid-state NMR methods using proton detection under Magic Angle Spinning (MAS) with frequencies up to 100 kHz.
The 100 kHz MAS probe head is a prototype and will allow significant gains in sensitivity by scaling down the 1H-1H dipolar coupling interaction and resulting in narrow proton line width down to 10-20 Hz.
Small quantities of protein samples in the range of 0.3 to 0.5 mg allow a signal-to noise ratio that exceeds that of tens of mg in a bigg…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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