CORDIS Project
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This project investigates the interaction between small multidrug resistance proteins and various substrates using solid-state nuclear magnetic resonance and other biochemical methods. The goal is to understand the mechanisms of drug resistance in bacteria, which is crucial for developing effective treatments for infec…
Small multidrug resistance proteins (SMR) were proven to be one of the responsible factors for drug resistance of bacteria, which represents an actual and serious problem in the therapy of several infectious diseases.
Despite of the recent extensive biochemical investigations of SMR proteins the mechanism of substrate recognition and translocation is not yet clearly understood.
The aim of the proposed project is the investigation of substrate-protein interaction between a selected SMR protein (e…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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