CORDIS Project
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This research focuses on understanding how chromatin structure affects gene transcription through the study of insulator proteins in fruit flies. By employing advanced imaging and modeling techniques, it aims to reveal the dynamic regulation of chromatin and its implications for cellular processes.
Eukaryotic chromosomes are condensed into several hierarchical levels of complexity:
DNA is wrapped around core histones to form nucleosomes, nucleosomes form a higher-order structure called chromatin, and chromatin is subsequently organized by long-range contacts.
The conformation of chromatin at these three levels greatly influences DNA transcription.
One class of chromatin regulatory proteins called insulator factors set up boundaries between heterochromatin and euchromatin and generate long-…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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