CORDIS Project
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This project aims to develop advanced microscopy techniques to study DNA replication processes at a single-molecule level. By focusing on the dynamics of replication forks in fission yeast, it seeks to enhance understanding of genomic stability and the mechanisms behind DNA damage repair.
Accurate DNA replication is key to maintaining genomic stability.
Replication is immensely complex requiring error-free duplication of several billion bases each time a human cell divides.
The DNA replication machinery must deal with a wide range of DNA damage, aberrant secondary structures and DNA:protein complexes; obstacles that cause replication forks to arrest.
Arrested replication complexes are actively stabilised by checkpoint pathways, but in some cases component proteins still dissociat…
THE UNIVERSITY OF SUSSEX
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