CORDIS Project
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This project aims to enhance gene targeting techniques in regenerative medicine by designing meganucleases that can create specific DNA breaks. These advancements could lead to new therapies for monogenic diseases and complex disorders like leukemias.
Regenerative medicine using gene targeting by homologous recombination is one of the most powerful methods to achieve precise genome modifications.
In the absence of double strand breaks the frequency of homologues recombination events at a target site is very low. A wide range of molecular tools are used to achieve targeting double strand breaks to increase the efficiency of homologues recombination.
Meganucleases are a class of homing endonucleases that can recognize long DNA sequences with hi…
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