CORDIS Project
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This project aims to develop supramolecular attack particles (SMAPs) as a novel cancer therapy targeting glioblastoma and ovarian cancer. These particles, derived from immune cells, can autonomously kill cancer cells and may reduce tumor recurrence after surgery.
Supramolecular attack particles (SMAPs) are proteinaceous particles ~120 nm in diameter released from cytotoxic T cell and natural killer cells.
The particles have a core of cytotoxic proteins including perforin andgranzymes enveloped in a dense shell of glycoproteins including thrombospondin-1, which provides specificity for SMAP mediated killing. SMAPs released from T-cells are stable for at least 24 hours and can kill target cells autonomously.
The human cell line NK92 secretes SMAPs based…
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