CORDIS Project
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This project investigates the regulation of gene expression through small RNA silencing pathways in fission yeast. It focuses on a newly discovered class of small RNAs, called priRNAs, and their role in gene regulation and protection against genomic instability, with implications for understanding cancer development.
Regulation of genome expression is essential for cell proliferation, differentiation, development and viability.
Small RNA silencing pathways are involved in the cellular control of gene expression and in protection of the genome against mobile repetitive DNA sequences, retroelements and transposons.
Small RNAs interact with target RNAs and promote chromatin modifications, translational inhibition or degradation of complementary RNAs.
We have uncovered new class of small RNAs in fission yeast, p…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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