CORDIS Project
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This project investigates the role of sleep in regulating synaptic changes in neurons using a zebrafish model. It aims to understand how sleep pressure influences synaptic dynamics and neuronal activity, providing insights into the biological functions of sleep.
Sleep is essential, yet its core functions and regulatory mechanisms are not fully understood.
The synaptic homeostasis hypothesis suggests sleep helps normalize synapse strength and number accumulated during wakefulness.
We have developed a zebrafish model for directly visualizing dynamic synaptic changes in single neurons across sleep/wake states.
Our research indicates that synaptic changes in single neurons vary significantly across similar neuronal types under baseline conditions.
Notably,…
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