CORDIS Project
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This project aims to develop mathematical models to understand the aggregation of misfolded proteins in amyloid diseases. By analyzing fibril reactions, it seeks to identify key mechanisms of polymerization and potential therapeutic targets.
Amyloid diseases are of increasing concern in our aging society.
These diseases all involve the aggregation of misfolded proteins, called amyloid, which are specific for each disease (PrP for Prion, Abeta for Alzheimer's).
When misfolded these proteins propagate the abnormal configuration and aggregate to others, forming very long polymers also called fibrils.
Elucidating the intrinsic mechanisms of these chain reactions is a major challenge of molecular biology: do polymers break or coalesce? D…
INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE
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Austria, Wien
Type: Research institute
Activity type: Research Organisations
SME: No
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