CORDIS Project
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This project aims to explore the biology of tissue-resident memory T cells, which play a crucial role in immune responses. It focuses on understanding their development and function in skin and gut tissues to inform future immunotherapy strategies.
Tissue-resident memory (Trm) cells are non-circulating T lymphocytes of non-lymphoid tissues and organs that provide localized protection at barrier surfaces such as skin, gut and lungs.
In human skin, Trm cells represent the predominant lymphocyte population, comprising subsets with different cytokine profiles and cytotoxic capacity.
They represent an integral part of barrier immunity, mounting tailored responses to diverse pathogens, but potentially also eliciting immune pathology.
Trm cell di…
KAROLINSKA INSTITUTET
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