CORDIS Project
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This project investigates the mechanisms behind skin cancers arising from pre-malignant transformations in epithelial tissues. By studying a rare genetic condition and utilizing mouse models, it aims to identify signaling pathways that lead to the expansion of susceptible stem cell populations, potentially informing fu…
Epithelia provide a protective barrier that exposes them to environmental carcinogens.
Cancers of epithelial tissues, called carcinoma, account for 85% of all cancers and 78% of all cancer associated mortality.
Epithelia undergo continual proliferation and renewal with hierarchical differentiation dependent upon long lived adult tissue stem cell.
Many carcinomas arise from pre-malignant transformation, intraepithelial neoplasia referred to as field cancerisation (FC), which is an area that can g…
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