CORDIS Project
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This project focuses on developing new small interfering RNA (siRNA) conjugates to improve the delivery of gene therapies for genetic skin disorders. The goal is to create efficient methods for transporting siRNAs into skin cells, enhancing their therapeutic potential.
The ability to target gene expression with nucleic acid-based therapeutics including small interfering RNAs (siRNAs) has opened up novel treatment opportunities for genetic skin disorders.
Although siRNAs have exquisite selectivity and potency, translation to the clinic has been hampered due to the lack of efficient delivery systems that allow penetration through the outer barrier of the skin, the stratum corneum, and uptake by the live cells of the dermis and epidermis. A number of physical and…
UNIVERSITY OF DUNDEE
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