CORDIS Project
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This project aims to uncover the mechanisms of DNA replication termination and the associated replication stress that can lead to cancer and neurodegeneration. By using advanced imaging techniques, it seeks to observe the dynamics of replication forks and identify potential therapeutic targets.
Replication-stress is a key driving force of cancer development, neurodegeneration and ageing.
Many sources of replication stress associated with the initiation and elongation phases of DNA replication have been discovered.
In contrast, little is known about the mechanisms of replication termination and termination-associated replication stress.
Recent breakthroughs identified the first elements of a mechanism of replication termination that involved ubiquitination of the Mcm7 subunit of the CMG…
THE UNIVERSITY OF BIRMINGHAM
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