CORDIS Project
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SINGuLAR investigates kidney adaptation in living donors to understand compensatory growth after loss of kidney mass. By analyzing urine-derived cells, it aims to uncover insights into kidney biology that could improve treatments for kidney injuries.
>850 million people are affected by kidney disease, which is caused by kidney injury.
Following injury, kidney cells have a remarkable ability to adapt.
Previous studies have largely focused on kidney injury signatures, yet treatments successfully targeting injury in animals have failed in humans.
Studies focused not on injury but on adaptation are lacking.
The main reason for this is that studying kidney adaptation with existing methods is challenging due to the low signal-to-noise ratio of ada…
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