CORDIS Project
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This project develops innovative tools to study DNA replication at the single-molecule level, focusing on large protein complexes involved in the process. By measuring DNA's physical properties and visualizing replication proteins, the research aims to uncover the mechanisms controlling DNA replication in various biolo…
The study of biological processes at the single-molecule level has greatly influenced our view of the molecular mechanisms that define life.
However, studies so far have mainly focused on individual, purified proteins in non-physiological environments.
Since cellular processes are typically not mediated by single proteins, but rather by large complexes of dynamically interacting components, the development of the tools to study such large complexes with single-molecule sensitivity is an importan…
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