CORDIS Project
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This project explores how proteins achieve their proper three-dimensional structure within cells using advanced single molecule fluorescence spectroscopy and Förster resonance energy transfer techniques. By focusing on molecular chaperones, it aims to enhance understanding of protein folding dynamics and their implicat…
Many aspects of the physical principles governing protein folding in vitro have been elucidated in the past decades.
At the same time, a large number of cellular components involved in protein folding in vivo have been identified.
But our mechanistic understanding of how these cellular components affect the energy landscape of the folding process has remained very limited, largely due to a lack of suitable methods.
An opportunity to bridge this gap is single molecule fluorescence spectroscopy in…
University of Zurich
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