CORDIS Project
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This project aims to enhance the accuracy of tumor ploidy predictions in sarcomas using Hematoxylin and Eosin stained images. By developing a model to analyze nuclei at a single-cell level, it seeks to improve diagnostic and prognostic capabilities for rare cancers.
Sarcomas are a diverse group of rare cancers that originate from mesenchymal tissues.
The rarity and intrinsic genetic complexity of sarcoma have made it one of the most challenging tumours to diagnose and consequently, to treat. A key genetic characteristic of many sarcoma subtypes is aneuploidy.
Aneuploidy is defined by losses and gains of chromosomes, and is a prognostic marker for a variety of sarcomas.
Currently, tumour ploidy are most commonly estimated using copy number alteration calling…
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