CORDIS Project
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This project investigates X-inactivation, focusing on how specific chromatin modifications influence gene silencing and heterochromatin formation in female cells. By studying the roles of various chromatin factors, the research aims to enhance understanding of gene regulation mechanisms.
X-inactivation (XCI) is an epigenetic phenomenon resulting in transcriptional silencing to attain gene dosage parity between XX females and XY males. XCI involves coating of the non-coding Xist RNA followed by depletion of euchromatic marks and shortly after accumulation of heterochromatic marks.
The chromatin modifying activities that are involved in these steps and their functional interplay remain poorly understood however.
We will specifically assess how euchromatic marks, such as H3K4 methy…
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