CORDIS Project
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This project investigates the role of synonymous mutations in cancer, which have been overlooked in previous research. By analyzing tumor samples and developing new bioinformatics tools, the project aims to identify and experimentally validate these mutations, shedding light on their potential impact on gene expression…
Our genome contains 20 000 genes, which are transcribed into mRNAs.
These mRNAs are then in turn translated into proteins that exert the cellular functions.
In the past decade, researchers have analysed the genetic sequence of all protein coding genes in thousands of tumor samples, with the aim to identify gene defects (‘mutations’) that cause cancer.
In most of these studies, only gene mutations that cause amino acid changes in the proteins for which they encode were analysed, and it was assume…
KATHOLIEKE UNIVERSITEIT LEUVEN
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