CORDIS Project
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This project investigates the molecular mechanisms behind the dual role of the Glucocorticoid Receptor in regulating inflammation. By identifying how this receptor can both activate and silence genes, it aims to improve therapies for inflammatory diseases while minimizing side effects.
I propose to decipher the unresolved molecular paradox of positive versus negative gene regulation by the Glucocorticoid Receptor (GR). GR is one of the most potent anti-inflammatory drug targets in clinical use today, and one of the most powerful metabolic regulators.
Unfortunately, its unique ability to efficiently shut off inflammatory gene expression is accompanied by serious side effects.
These undesired effects are attributed to the transcriptional activation of its metabolic target genes…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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