CORDIS Project
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This project aims to explore the interaction between an Olfactory Receptor and its G protein, focusing on structural analysis and activation mechanisms. The goal is to understand how these receptors function and their potential applications in drug development.
G protein coupled receptors form the largest and most important class of cell surface receptors with a seven transmembrane fold.
These proteins mediate diverse cell responses as reaction to input signals like hormones, peptides, light and endogenous ligands.
Due to their central role, most drugs on the market target these receptors.In 2011 and 2012 incredible advance has been published in terms of X-ray structural data on GPCRs.
Nevertheless, the actual mode of action and structural rearrangemen…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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