CORDIS Project
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This project investigates the role of NOD-like receptors in immune responses, focusing on their signaling pathways in health and disease. By studying specific receptors, it aims to enhance understanding of immune signaling and its implications for infections and autoimmune conditions.
My overall aim is to define the role of NOD-like receptors (NLRs) in immunity and to understand the importance of their signaling networks in health and disease.NLR family members are thought to sense pathogens and endogenous alarmins in intracellular compartments to trigger innate immune responses.
Recent progress was made in mapping the signaling pathways of the NLRs Nod1, Nod2 and Nlrp3, but the roles and signaling cascades of most other NLRs remain unclear.
Indeed, the NLRs Ipaf and Nlrp1b a…
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