CORDIS Project
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This project explores the fundamental mechanisms of integrin-mediated cell adhesion, focusing on how integrins transition between active and inactive states. The research aims to clarify the role of integrins in cellular signaling and their implications for development and disease.
Integrin-mediated cell adhesion is essential for the development and homeostasis of multicellular organisms.
Integrins are ubiquitously expressed heterodimeric adhesion receptors consisting of α and β subunits.
They exhibit two striking properties; they can regulate their affinity for ligands and assemble large signalling hubs called adhesomes.
Both properties depend on the α and β cytoplasmic tails; when integrins switch from inactive to active conformations their weakly associated tails separa…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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