CORDIS Project
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This project investigates small heat shock proteins (sHSPs) to understand their 3D structures and interactions with other proteins. By using advanced imaging techniques, the goal is to uncover how these proteins prevent harmful aggregation in cells, which is relevant for diseases like cataracts and neurodegenerative di…
Small heat shock proteins (sHSPs) are a family of proteins that play a crucial role in the cell.
The sHSPs bind to proteins that have partially unfolded and prevent them from forming deleterious intracellular aggregates.
In humans high levels of sHSPs are found in various tissues.
Aberrant sHSP activity, or the loss of it, is associated with a variety of diseases including cataract, myopathy and neurodegenerative diseases.
Additionally, high levels of sHSPs protect cancer cells from chemotherape…
KATHOLIEKE UNIVERSITEIT LEUVEN
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