CORDIS Project
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This project investigates the mechanisms that block the Homology Directed Repair pathway in gene editing using CRISPR-Cas technology. By understanding the role of the 53BP1-Shieldin complex, the research aims to enhance gene editing efficiency, particularly for medical applications in personalized medicine.
Genome editing has triggered a revolution with stark implications in life science.
Recently, a new gene-editing technique CRISPR-Cas has become dominant in laboratory conditions.
The first step in a targeted genome modification requires the CRISPR-Cas nuclease to generate a specific DNA double-strand break (DSB).
Eukaryotic cells repair the DSBs by the fast but potentially mutagenic Non-Homologous End Joining (NHEJ), and by the accurate Homology Directed Repair (HDR) pathways.
Gene editing techn…
KOBENHAVNS UNIVERSITET
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