CORDIS Project
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This project investigates the role of the Shelterin complex in maintaining telomere stability in mammalian cells. Using advanced single-molecule techniques, it aims to understand how Shelterin interacts with chromatin and its implications for genome stability and cancer therapy.
The linear ends of eukaryotic chromosomes are formed by telomeres, nucleoprotein structures containing double-stranded TTAGGG repeats, ending in a single-stranded DNA 3-overhang.
In mammalian cells, the six-subunits Shelterin complex binds telomeres and is critical for telomere homeostasis.
Shelterin ensures faithful replication of telomeric DNA, hides linear ends in a looped structure to prevent their recognition as DNA breaks and ensures control over telomere length.
Telomeres are packed into…
THE FRANCIS CRICK INSTITUTE LIMITED
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