CORDIS Project
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This project focuses on developing a method for modifying large ring structures in bioactive compounds, particularly epothilone C, to improve their properties for drug discovery. It employs advanced chemical techniques to alter molecular shapes and enhance efficacy while reducing toxicity.
Bioactive macrocyclic compounds are valuable platforms in drug discovery.
More often than not, natural products represent attractive leads, the structures of which may be altered by chemical synthesis to enhance efficacy, lower toxicity, and superior physicochemical properties.
The proposed project aims to a practical and programmable strategy for precise skeletal editing of large ring structures by aligning catalytic ring-opening metathesis, site- and/or stereoselective modification of the line…
UNIVERSITE DE STRASBOURG
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