CORDIS Project
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This project investigates the interactions between the layers of Gram-negative bacteria that contribute to their antibiotic resistance. By exploring the assembly of key components and their coordination, the research aims to uncover mechanisms that maintain bacterial envelope integrity and resilience.
Gram-negative bacteria are notoriously resilient, dominating the list of pathogens requiring urgent medical attention.
Fundamental to their remarkable antibiotic resistance is a tripartite envelope comprised of an inner-membrane (IM), peptidoglycan cell wall (PG) and an outer membrane (OM).
While these layers were previously viewed as separate compartments, it is becoming apparent that they work together in order to maintain envelope integrity.
However, little is known about the crosstalk betwee…
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