CORDIS Project
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This project investigates how estrogen signaling in astrocytes affects energy balance and obesity, focusing on sex-specific adaptations in the hypothalamus. By exploring the role of astrocytes in energy metabolism, it aims to develop targeted therapies for obesity and related conditions.
Obesity is a complex condition that causes around 1.6 million deaths each year.
The metabolic alterations to an obesigenic environment are highly dependent on the sex of the individual.
In the brain, the hypothalamus controls energy homeostasis by fine tuning feeding and energy expenditure to nutrient availability.
Disruption of this regulation results in obesity.
While hypothalamic neurons are crucial for the control of energy balance, their activity is tightly dependent on adequate delivery o…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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