CORDIS Project
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This project aims to develop a system for creating unnatural polymers in cells by engineering specific tRNA and synthetase pairs. The approach involves modular and scalable techniques to expand the genetic code, allowing for the incorporation of non-standard amino acids into proteins.
We will build an orthogonal translation system for the encoded synthesis of unnatural polymers in cells.
The steps towards this goal are each significant and substantial and, importantly, our solutions for each step are both scalable and modular with those for other steps in the process.
In the first step we create a scalable and modular route to multiple new aminoacyl-tRNA synthetase/tRNA pairs that are orthogonal to each other and to endogenous synthetases and tRNAs.
In a second step we eng…
UNITED KINGDOM RESEARCH AND INNOVATION
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