CORDIS Project
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This project investigates the mechanisms by which the HGF/SF and MET signaling pathways promote cancer cell invasion and metastasis. It aims to develop therapeutic agents targeting these pathways, including protein antagonists and small molecule inhibitors, to combat metastatic cancer effectively.
The growth and motility factor HGF/SF and its receptor MET define a paracrine signalling system which controls the migration of several cell lineages in embryogenesis and tissue repair.
In a large number of human tumours, cancer cells hijack HGF/SF and MET signalling in order to invade adjacent tissue and initiate metastasis.
The evidence for this is strong, broad and consistent and highlights HGF/SF and MET as key effectors of tumour invasion and primary targets for therapy.
This proposal h…
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