CORDIS Project
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This research focuses on the role of serotonin in regulating brain activity related to working memory. By studying specific brain cells in mice, the project aims to uncover mechanisms that could lead to better treatments for cognitive deficits in mental health disorders.
Functional integrity of the prefrontal cortex (PFC) is essential for higher ‘executive’ functions such as working memory (WM).
Serotonin (5-HT) modulates GABAergic neurotransmission in the PFC through different 5-HT receptor subtypes that are selectively expressed in distinct GABAergic cell types.
Altered GABAergic neurotransmission in the PFC of patients suffering from schizophrenia and depression is believed to be central to their pathophysiology.
Currently available treatments targeting 5-HT…
THE FRANCIS CRICK INSTITUTE LIMITED
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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom, LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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