CORDIS Project
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This project investigates idiopathic scoliosis in adolescents using zebrafish as a model. It aims to understand the role of serotoninergic neurons and the Reissner Fibre in maintaining spine alignment, potentially leading to insights for developing diagnostic tools for scoliosis.
Idiopatic scoliosis (IS) is a human pathology that affects 1-4% of adolescents worldwide, who suffer from spine deformities for which an effective treatment is not currently available.
At present, evidence for genetic causes of IS exist, but the aetiology of this pathology is still not understood.
The zebrafish is a powerful organism to model human pathologies that entail body axis misalignment as, by swimming in a viscous liquid, its spine is subject to forces similar to the ones acting on the…
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
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