CORDIS Project
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This project focuses on linking genetic variants in noncoding regions of the human genome to disease outcomes. By developing advanced genome editing techniques, it aims to generate functional data that can improve precision diagnostics and targeted therapies.
Deciphering how genetic variants lead to disease can advance precision diagnostics and mechanistically informed therapies.
Yet, our ability to link variants in the human genome’s vast noncoding regions to phenotypic consequences is highly limited.
This stems largely from a lack of experimental evidence on individual variants’ functional effects.
Here, we propose to develop and deploy a suite of new genome editing methods to generate functional data for noncoding variants at unprecedented scale.F…
THE FRANCIS CRICK INSTITUTE LIMITED
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