CORDIS Project
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This project aims to uncover the regulatory mechanisms of peptidoglycan hydrolases in bacterial cell division, particularly in Staphylococcus aureus. By studying these enzymes, the research seeks to understand their role in bacterial growth and potential implications for antibiotic resistance.
Peptidoglycan (PG) hydrolases are instrumental in mediating bacterial daughter cell separation via septum splitting, an essential process for the ability of bacteria to multiply.
In a gram-positive pathogen such as Staphylococcus aureus, the division septum is completed before PG hydrolases initiate septum splitting. S. aureus is an important pathogen, as it is one of the most common causes of death by antibiotic resistant infections.
Premature splitting of the division septum could expose an im…
UNIVERSIDADE NOVA DE LISBOA
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