CORDIS Project
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The SENTINEL project investigates the interplay between metabolic pathways and immune responses in cells. It aims to understand how the regulation of certain proteins affects tissue homeostasis and immune functions, particularly in conditions with chronic immune activation.
Metabolic and immune pathways form an intricate network that maintains homeostasis.
We recently unveiled that the Stimulator of Interferon Genes (STING), central to triggering cytosolic dsDNA-dependent type I Interferon (IFN) responses, inhibits the desaturation of essential dietary polyunsaturated fatty acids (PUFAs). STING thereby controls the generation of long-chain PUFAs (LC-PUFAs) that in turn inhibit STING activation.
This double negative regulatory feedback loop operates as a key rheosta…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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