CORDIS Project
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This project investigates the dynamic behavior of MYC proteins in human tumors, focusing on their transition between different biochemical states in response to transcriptional stress. It aims to understand how these changes contribute to tumor growth and explore therapeutic strategies to inhibit MYC multimerization, p…
Deregulated expression of MYC or one of its paralogues, MYCN and MYCL, maintains the growth of most human tumors.
All current models explain the oncogenic potential of MYC proteins by their ability to form complexes with MAX that universally bind to active promoters and the ability of these complexes to induce a tumor-specific gene expression pattern.
While MYC conforms to this model during unperturbed cell growth, we have discovered two paradigmatic situations in which MYC proteins undergo fund…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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