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The SelfOrg project investigates how intrinsic self-organization in cancer cells contributes to tumor heterogeneity and resistance in colorectal cancer. By studying organoids and mouse models, the research aims to uncover new therapeutic targets to improve patient outcomes.
Colorectal cancer (CRC) remains a major health challenge, with a survival rate of 15% in stage IV cases due to therapy resistance and tumor relapse. A key barrier to effective treatment is the high degree of intratumor heterogeneity and plasticity.
These features enable the coexistance of diverse cancer cell populations within a tumor, each of them specialized in key functions such as proliferation, invasion or resistance to treatment.
Additionally, phenotypic plasticity grant these cancer cells…
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
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