CORDIS Project
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This project aims to revolutionize nanomedicine by creating diverse libraries of DNA nanostructures for applications in drug delivery and diagnostics. By leveraging evolutionary selection methods, it seeks to optimize the performance of DNA-based binders and enhance specificity in targeting pathogenic proteins and canc…
In nanomedicine, patterns, shapes and mechanics are tuned to improve performance in applications such as drug delivery and pattern matching binders. A fundamental bottleneck is that structures need to be individually assembled and tested limiting the number that can be screened and likely missing structures with optimal performance.
In this proposal we describe a new class of DNA nanostructures, assembled as diverse libraries of branched DNA wireframes with complex 3D shapes that fold from sing…
KAROLINSKA INSTITUTET
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