CORDIS Project
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This project aims to understand the structure and interactions of the Type II Secretion System pseudopilus in Gram-negative bacteria using solid-state nuclear magnetic resonance. By elucidating its assembly, the project seeks to advance knowledge of bacterial protein transport mechanisms.
Many cellular processes rely on multi-functional molecular nanomachines, such as the ribosome (protein synthesis), bacterial pili and needles (host-pathogen interaction) or flagella (cell motion).
These machines are built by the assembly of multiple copies of protein subunits into large macromolecular structures, also called supramolecular assemblies.
Understanding assembly, structure and functions of these machines is hampered by the challenging structural characterization task.
Indeed, these i…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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