CORDIS Project
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This project studies the mechanisms behind therapy-related malignancies in childhood cancer survivors. By analyzing mutation patterns and cellular origins, it aims to uncover how chemotherapy contributes to the development of second cancers.
Therapy-related malignancies are a major cause of long-term mortality among childhood cancer survivors.
However, it is unclear how exposure to chemo- and/or radiotherapy early in life induces carcinogenesis.
My aim is to determine the mechanisms and rate-limiting steps underlying the genesis of second malignancies in childhood cancer survivors.
For this, we will focus on studying the etiology of therapy-related myeloid malignancies (t-MNs). I have pioneered methods to characterize mutation accum…
PrinsesMaximaCentrumvoorKinderoncologie
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
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