CORDIS Project
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This project focuses on enhancing targeted protein degradation by discovering new ligands for E3 ligases, which are crucial for degrading difficult-to-target proteins. It employs innovative techniques to identify PROTACable sites and develop novel degraders, aiming to broaden the therapeutic applications of this strate…
Targeted protein degradation (TPD) via the ubiquitin-proteasome system (UPS) has emerged as a powerful therapeutic strategy with the potential to tackle “undruggable” proteins by surpassing occupancy-driven inhibition.
Degraders are mainly classified into molecular glue degraders (MGDs) and proteolysis-targeting chimeras (PROTACs).
Despite the clinical success of MGDs such as thalidomide and the progress of over 50 degrader candidates into clinical trials, current approaches rely heavily on a sm…
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