CORDIS Project
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This research focuses on understanding how African trypanosomes express a single variant surface glycoprotein, which is crucial for their infectivity and survival. Using advanced single-cell RNA sequencing, the project aims to reveal insights into gene expression and the biology of this significant pathogen.
African trypanosomes are flagellated parasitic protozoans that cause the devastating, lethal disease sleeping sickness, as well as causing economically damaging livestock infections across sub-Saharan Africa.
Trypanosomiasis was targeted for elimination by the WHO and others in the London declaration by 2020.
Trypanosomes are transmitted by the bite of an infected tsetse fly, which restricts their geographic distribution.
In the salivary gland of the fly, parasites coat their surface with approx…
INSTITUT PASTEUR
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