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SCRIBE focuses on developing innovative strategies for gene writing using RNA and CRISPR technology. The project aims to create a new family of tools for precise genetic modifications, enhancing both research and practical applications in genetic engineering.
CRISPR development has enormously accelerated genetic engineering principles, and precise methods to modify small alleles (such as base or prime editing) are now available.
However, generating large genomic changes still presents enormous challenges.
Large modifications, such as gene transfers, are performed generally with viral vectors, which have been associated with toxicities in the clinic, and often lack versatility needed for basic science experimentation.
Newer CRISPR-based techniques for…
UNIVERSIDAD POMPEU FABRA
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