CORDIS Project
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This project investigates how RNA regulates key enzymes involved in stem cell differentiation, focusing on the hematopoietic system. By analyzing RNA-protein interactions in primary stem cells and their differentiated progeny, the research aims to uncover the role of riboregulation in these processes.
Although multiple regulatory layers have been reported to control stem cell differentiation, including epigenetics, cell signaling and metabolism, we still lack sufficient knowledge on how differentiation processes are connected and coordinated.
The Hentze laboratory recently discovered that RNA modulates (riboregulates) the activity of the glycolytic enzyme Enolase 1 (ENO1) and that this interaction is essential for in vitro murine embryonic stem cell differentiation.
Additionally, unpublished…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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