CORDIS Project
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This project investigates the role of immune cells in regulating the fate of endogenous neural stem cells in the spinal cord after injury. By understanding the interactions between immune responses and stem cell behavior, the research aims to develop targeted therapies that promote the generation of neurons and oligode…
Despite endogenous neural stem cells (eNSCs) being present in the adult mammalian central nervous system (CNS), their neuronal potential upon injury is rarely achieved in the brain and never in the spinal cord (SC) environment.
This makes widespread SC injuries (SCIs) especially challenging to treat.
Even though SC eNSCs give rise to astrocytes, oligodendrocytes, and neurons in vitro, they almost exclusively generate glial scar-forming astrocytes, seldom myelinating oligodendrocytes, and never n…
KAROLINSKA INSTITUTET
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