CORDIS Project
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This project investigates the complex interactions within the yeast genome to enhance drug discovery. By identifying chemical and genetic interactions, it aims to develop a comprehensive matrix that predicts how small molecules can selectively target specific biological responses, aiding in therapeutic interventions.
Recent genome-scale studies have revealed the massive redundancies and functional interconnectivities encoded by the genome.
For example, the budding yeast Saccharomyces cerevisiae is predicted to harbor 200,000 synthetic lethal interactions.
This genetic density has profound implications for both understanding the architecture of living systems and drug discovery.
In particular, the dense connections of biological networks mandate a multi-node strategy to selectively manipulate any given biolog…
THE UNIVERSITY OF EDINBURGH
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