CORDIS Project
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This research investigates the mechanisms of drug resistance in acute myeloid leukaemia by linking epigenetic changes to treatment responses. Using advanced single-cell sequencing methods, it aims to uncover insights that could lead to new strategies for overcoming resistance to targeted therapies.
Novel targeted therapies are increasingly applied against a wide range of cancers.
Although such agents can induce cures, most patients suffer from relapsed disease.
Acute myeloid leukaemia (AML) is a prime example of a deadly disease, but we have a chance to dramatically improve outcomes if we can better understand resistance mechanisms against targeted agents that are transforming AML treatment, such as the BCL2 inhibitor venetoclax. AML is characterised by profound alterations in the epigenom…
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